TABLE 1

Ulcer area in DCF-treated IE-Cpr-null and WT mice

Mice were treated with DCF (50 mg/kg) or vehicle alone as described in the legend to Fig. 1D. Ulcer area was determined as described under Materials and Methods. Values reported represent means ± S.D. (n = 5–6).

StrainTreatmentTotal Ulcer Area Along the SI
1st Quartile2nd Quartile3rd Quartile4th QuartileCombined
mm2
WTVehicle00000
DCF005.49 ± 0.3711.30 ± 5.2016.79 ± 3.41
IE-Cpr-nullVehicle00000
DCF002.27 ± 0.18a0.37 ± 0.09a2.64 ± 0.06a
  • a p < 0.01, compared with the corresponding vehicle-treated group (Student's t test).