TABLE 1

Gene expression in Abcg2(−/−) rats over Abcg2(+/+) rats

Gene expression was normalized to 18s rRNA, glyceraldehyde-3-phosphate dehydrogenase, or β-actin. Values are mean ± S.D. of mRNA expression ratio [Abcg2(−/−)/Abcg2(+/+)]; n = 6 (except the brain). Pooled capillary-enriched fraction was used for the brain.

Common Name	Gene Symbol	Liver	Brain	Kidney	Duodenum	Jejunum	Ileum
Mdr1a	Abcb1a	1.00 ± 0.07	0.80	0.79 ± 0.29	1.35 ± 0.56	0.97 ± 0.05	0.57 ± 0.06
Mdr1b	Abcb1b	0.32 ± 0.07^*	0.58	1.07 ± 0.22	0.79 ± 0.08	1.57 ± 0.18	N.D.
Mdr3	Abcb4	0.81 ± 0.25	N.D.	N.D.	N.D.	N.D.	N.D.
Bsep	Abcb11	0.62 ± 0.26	N.D.	0.84 ± 0.42	0.73 ± 0.18	1.21 ± 0.11	0.44 ± 0.04^*
Mrp1	Abc1	N.D.	0.54	0.75 ± 0.31	1.62 ± 0.16	1.73 ± 0.26	1.41 ± 0.08
Mrp2	Abcc2	0.63 ± 0.21	N.D.	0.90 ± 0.37	0.96 ± 0.10	1.21 ± 0.17	0.32 ± 0.06^*
Mrp3	Abcc3	0.39 ± 0.17^*	4.45	1.18 ± 0.36	1.92 ± 0.01	1.03 ± 0.18	1.73 ± 0.25
Mrp4	Abcc4	1.02 ± 0.17	0.80	0.95 ± 0.38	1.70 ± 0.28	1.03 ± 0.09	0.95 ± 0.05
Mrp5	Abcc5	N.D.	0.76	0.88 ± 0.58	1.77 ± 0.63	0.97 ± 0.12	1.15 ± 0.08
Mrp6	Abcc6	0.56 ± 0.17	0.79	0.80 ± 0.48	2.17 ± 0.71^*	2.37 ± 0.37^*	1.14 ± 0.12
Bcrp	Abcg2	0.01 ± 0.01^*	0.00	0.00 ± 0.01^*	0.00 ± 0.00^*	0.00 ± 0.00^*	0.00 ± 0.00^*
N.A.	Abcg5	0.46 ± 0.20^*	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Abcg8	0.90 ± 0.29	N.D.	N.D.	N.D.	N.D.	N.D.
Oatp1a1	Slco1a1	0.72 ± 0.26	N.D.	1.15 ± 0.54	N.D.	N.D.	N.D.
Oatp1a4	Slco1a4	0.87 ± 0.25	0.15	1.55 ± 0.41	N.D.	N.D.	N.D.
Oatp1a5	Slco1a5	N.D.	1.30	N.D.	N.D.	N.D.	N.D.
Oatp1a6	Slco1a6	N.D.	N.D.	1.20 ± 0.57	N.D.	N.D.	N.D.
Oatp1b3	Slco1b3	1.06 ± 0.17	N.D.	N.D.	N.D.	N.D.	N.D.
Oatp2b1	Slco2b1	0.50 ± 0.13	1.50	0.95 ± 0.30	2.13 ± 0.20^*	1.63 ± 0.07	0.92 ± 0.07
Oatp1c1	Slco1c1	N.D.	1.10	N.D.	N.D.	N.D.	N.D.
OATP4c1	Slco4c1	N.D.	0.62	1.32 ± 0.33	N.D.	N.D.	N.D.
Ntcp	Slc10a1	0.73 ± 0.17	N.D.	N.D.	N.D.	N.D.	N.D.
Asbt	Slc10a2	N.D.	N.D.	0.43 ± 0.21	2.11 ± 1.19^*	N.D.	4.2 ± 0.36^*
Pept1	Slc15a1	N.D.	N.D.	1.05 ± 0.35	0.90 ± 0.22	1.02 ± 0.07	0.64 ± 0.04
Pept2	Slc15a2	N.D.	0.80	0.80 ± 0.21	0.86 ± 0.33	0.31 ± 0.15^*	0.54 ± 0.09
Oat-k	Slc21a4	N.D.	N.D.	0.70 ± 0.15	N.D.	N.D.	N.D.
Oct1	Slc22a1	1.12 ± 0.25	N.D.	0.79 ± 0.21	1.64 ± 0.33	1.05 ± 0.13	0.67 ± 0.06
Oct2	Slc22a2	N.D.	1.35	1.24 ± 0.26	N.D.	N.D.	N.D.
OctN1	Slc22a4	N.D.	0.52	0.53 ± 0.21	0.89 ± 0.14	2.83 ± 0.33^*	1.03 ± 0.13
OctN2	Slc22a5	N.D.	2.38	0.84 ± 0.30	1.51 ± 0.24	1.27 ± 0.13	0.92 ± 0.07
Oat1	Slc22a6	N.D.	0.67	0.63 ± 0.22	N.D.	N.D.	N.D.
Oat2	Slc22a7	0.68 ± 0.20	N.D.	1.05 ± 0.39	0.70 ± 0.03	N.D.	N.D.
Oat3	Slc22a8	1.43 ± 0.32	0.68	0.91 ± 0.40	N.D.	N.D.	N.D.
Oat8	Slc22a9	N.D.	N.D.	1.16 ± 0.24	N.D.	N.D.	N.D.
Urat1	Slc22a12	N.D.	1.13	0.88 ± 0.45	N.D.	N.D.	N.D.
Mate1	Slc47a1	N.D.	1.12	0.91 ± 0.44	N.D.	N.D.	N.D.
N.A.	Cyp1a2	0.95 ± 0.22	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Cyp2b2	0.41 ± 0.18^*	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Cyp2c11	0.72 ± 0.25	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Cyp2c23	N.D.	N.D.	0.87 ± 0.18	N.D.	N.D.	N.D.
N.A.	Cyp2d4	0.84 ± 0.31	0.77	1.31 ± 0.42	1.58 ± 0.50	1.37 ± 0.09	0.67 ± 0.06
N.A.	Cyp3a2	0.65 ± 0.30	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Cyp3a9	N.D.	0.89	N.D.	0.97 ± 0.19	1.34 ± 0.15	0.54 ± 0.11
N.A.	Cyp3a18	N.D.	N.D.	N.D.	0.69 ± 0.19	1.12 ± 0.10	0.27 ± 0.05^*
N.A.	Cyp3a23/3a1	0.55 ± 0.15	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Cyp4a1	0.57 ± 0.18	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Ugt1a1	0.69 ± 0.20	N.D.	1.82 ± 0.43	1.74 ± 0.19	1.10 ± 0.04	0.70 ± 0.04
N.A.	Ugt1a6	0.92 ± 0.33	1.41	1.52 ± 0.42	1.04 ± 0.23	1.35 ± 0.07	0.75 ± 0.05
N.A.	Ugt1a7c	N.D.	0.91	1.04 ± 0.44	1.50 ± 0.00	1.16 ± 0.11	0.58 ± 0.06
N.A.	Ugt2b1	0.56 ± 0.21	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Ugt2b5	0.53 ± 0.24	N.D.	N.D.	N.D.	N.D.	N.D.
N.A.	Ugt2b7	N.D.	N.D.	1.74 ± 0.49	1.21 ± 0.48	N.D.	N.D.
N.A.	Ugt2b36	0.66 ± 0.24	N.D.	1.75 ± 0.55	0.59 ± 0.15	0.83 ± 0.17	N.D.

N.A., not available; N.D., not determined.
↵* Adjusted p < 0.05, fold change ≥2.