Receptor | pKi | M3 Selectivity Ratio | ||
---|---|---|---|---|
Tiotropium | NVA237 | Tiotropium | NVA237 | |
M1 | 10.34 ± 0.04 | 9.60 ± 0.03 | 1.07 | 0.98 |
M2 | 10.05 ± 0.03 | 8.70 ± 0.04 | 2.09 | 7.76 |
M3 | 10.37 ± 0.04 | 9.59 ± 0.05 | 1.00 | 1.00 |
M4 | 10.18 ± 0.07 | 9.06 ± 0.01 | 1.55 | 3.39 |
M5 | 9.76 ± 0.07 | 8.91 ± 0.04 | 4.07 | 4.79 |