Excretion and PK parameters of digoxin in Abcg2 (+/+) and Abcg2(−/−) rats
Values are mean ± S.D. for n = 3; individual value is reported for n = 2.
| Parameter | Abcg2(+/+) | Abcg2(−/−) |
|---|---|---|
| Biliary excretion, % of the dose | 6.4 ± 4.3 | 6.8 ± 1.7 |
| Urinary excretion, % of the dose | 20.0 ± 2.6 | 20.7 ± 6.0 |
| Systemic CL, l/h/kg | 1.4, 1.0 | 1.8, 1.4 |
| Oral AUC0-inf, μg · h/l | 327 ± 154 | 210 ± 180 |
| F, % | 37 ± 17 | 33 ± 29 |