AUC (μmol · h/l) of medium concentration of ATA without and with coincubation of E3S in fresh human hepatocytes and HepaRG cells at days 3 and 4 in bioreactor culture
The significance levels of difference in the average loss from media of E17βG with E3S compared with loss from media of E17βG without E3S are shown. Results shown are average ± S.D.
| Cells | Experiment | AUC ATA |
|---|---|---|
| Fresh hepatocytes | ATA | 21.1 ± 3.2 |
| Fresh hepatocytes | ATA + E3S (30 μM) | 24.6 ± 4.9* |
| HepaRG | ATA | 31.5 ± 5.6 |
| HepaRG | ATA + E3S (30 μM) | 32.5 ± 7.6 |
↵* , P = 0.08.