TABLE 5
Compound exposure associated with reversal of haloperidol-induced catalepsy
Estimated ED
50
, mg/kg
1.1
EC
50
, ng/ml, total plasma concentration
92
EC
50
, plasma nM
338
EC
50
, plasma unbound, nM
27
EC
50
, CSF, nM
23
In vitro EC
50
, nM
9.1