Latency | Change | ADX Plasma Exposure | CSF/rEC50 ratio | |
---|---|---|---|---|
s | % | ng/ml | ||
Haloperidol alone | 88.7 ± 6.9 | 0.0 | ||
ADX88178 0.01 mg/kg | 107.5 ± 6.4 | 21.2 | BLQ | |
ADX88178 0.1 mg/kg | 98.3 ± 7.0 | 10.8 | BLQ | |
ADX88178 0.3 mg/kg | 89.3 ± 10.2 | 0.7 | BLQ | |
ADX88178 1.0 mg/kg | 79.0 ± 11.4 | −10.9 | 27 ± 6 | 0.8 |
ADX88178 3.0 mg/kg | 33.4 ± 4.1** | −62.3 | 241 ± 35 | 6.8 |
ADX88178 10.0 mg/kg | 25.7 ± 6.8** | −71.0 | 943 ± 68 | 26.5 |
l-DOPA /benserazide | 21.3 ± 4.9** | −76.0 |
BLQ, below level of quantitation.
↵** Significantly different from haloperidol alone, p < 0.05, one-way ANOVA with Bonferroni correction.