TABLE 3

Chronic effects of KGA-2727 or acarbose on Ins-I and Fib-I of the pancreas in Zucker diabetic fatty rats

Data are presented as the means ± S.E.M. (n = 8).

	Lean Control	Obese (fa/fa)
		Control	KGA-2727			Acarbose, 100 ppm
		Control	10 ppm	30 ppm	100 ppm	Acarbose, 100 ppm
Ins-I, %	46.9 ± 1.9	17.4 ± 1.8^†††	19.0 ± 1.8	26.8 ± 2.4^**	37.6 ± 1.8^***	20.8 ± 1.1
Fib-I, %	3.25 ± 0.83	10.41 ± 1.50^†††	8.47 ± 0.96	7.25 ± 0.92	5.66 ± 1.09^*	8.53 ± 1.32

↵* , p < 0.05;
↵** , p < 0.01;
↵*** , p < 0.001 vs. the obese control group.
↵††† , p < 0.001 vs. the lean control group.