TABLE 5

Onset and duration of action of β-adrenergic receptor agonists in EFS isolated human bronchi

Onset and duration of action were determined by applying a single concentration of agonist that produced approximately 60% inhibition of the EFS-induced contraction. Onset of action was defined as the time spanning from agonist addition to the attainment of 50% of the maximal inhibition produced by the concentration added. Duration of action was defined as the time spanning from agonist washout to the attainment of 50% recovery from the inhibition produced by the concentration added. Onset and duration of action data are reported as mean ± S.E.M. n/p experiments involve the number of rings (n) and the number of patients (p).

CompoundConcentration Testedn/pOnset t1/2Duration of Action t1/2
nMmin
Abediterol305/57.4 ± 1.4691 ± 120*
Salmeterol3003/315.7 ± 6.7*860 ± 20*
Formoterol308/73.1 ± 0.6117 ± 50
Indacaterol304/46.5 ± 1.4616 ± 159*
  • * p < 0.05 versus the corresponding formoterol values (ANOVA followed by Bonferroni).