5-HT pEC50 values in the rat and mouse isolated trachea preparations
Data are expressed as mean ± S.E.M. of the number of animals indicated in parentheses.
| pEC50 | |||
|---|---|---|---|
| Rats | Wild-Type Mice | S1P3 Receptor-Deficient Mice | |
| Vehicle | 5.98 ± 0.13 (9) | 6.01 ± 0.02 (4) | 5.94 ± 0.03 (4) |
| FTY720, 0.1 μM | 6.02 ± 0.21 (3) | 6.04 ± 0.05 (4) | 5.98 ± 0.07 (4) |
| FTY720, 1 μM | 6.01 ± 0.15 (7) | 5.91 ± 0.07 (3) | 5.71 ± 0.06 (4) |
| FTY720, 10 μM | 6.06 ± 0.09 (11) | 6.04 ± 0.02 (5) | 6.07 ± 0.05 (4) |
| AUY954, 0.1 μM | 6.01 ± 0.08 (3) | 6.03 ± 0.04 (4) | 6.01 ± 0.01 (3) |
| AUY954, 1 μM | 6.03 ± 0.12 (4) | 6.09 ± 0.06 (3) | 5.97 ± 0.07 (3) |
| AUY954, 10 μM | 6.03 ± 0.05 (4) | 6.15 ± 0.05 (4) | 5.86 ± 0.06 (4) |