Lean Control | Obese (fa/fa) | |||||
---|---|---|---|---|---|---|
Control | KGA-2727 | Acarbose, 100 ppm | ||||
10 ppm | 30 ppm | 100 ppm | ||||
Glomerulosclerosis score | ||||||
0.17 ± 0.12 | 0.68 ± 0.05† | 0.80 ± 0.03 | 0.81 ± 0.03 | 0.75 ± 0.02 | 0.76 ± 0.03 | |
Glycogen deposition in distal tubules | ||||||
− | 8 | 0 | 4 | 7 | 8 | 6 |
± | 0 | 1 | 1 | 1 | 0 | 1 |
+ | 0 | 7 | 3 | 0 | 0 | 1 |
Significance | ††† | N.S. | *** | *** | *** | |
Dilatation of distal tubule | ||||||
− | 8 | 1 | 6 | 8 | 8 | 6 |
± | 0 | 0 | 2 | 0 | 0 | 2 |
+ | 0 | 7 | 0 | 0 | 0 | 0 |
Significance | — | ††† | ** | *** | *** | ** |