TABLE 1

Mean (S.E.M.) effect of selected doses of CP55940, URB597, and AM404 alone and in combination with 3.0 mg/kg SR141716A

SR141716A significantly attenuated the effects of each drug in each assay (determined by unpaired by t tests with an α level of significance of 0.05).

Drug Alone+ 3.0 mg/kg SR141716A
Hotplate, %MPE
    1.0 mg/kg CP55940100 (0.00)33.39 (8.30)
Acetic acid-elicited writhing, % inhibition
    0.32 mg/kg CP5594099.98 (0.02)4.76 (15.57)
    10.0 mg/kg URB59790.00 (4.19)13.02 (19.06)
    10.0 mg/kg AM40437.78 (14.74)3.50 (3.06)
Acetic acid-suppressed feeding, % control
    10.0 mg/kg URB59772.48 (11.90)5.58 (1.09)
Acetic acid-suppressed running, % control
    10.0 mg/kg URB59754.08 (12.73)9.94 (5.82)
    10.0 mg/kg AM40431.18 (9.87)5.09 (2.73)
Schedule-controlled behavior, % control
    0.1 mg/kg CP559401.06 (0.66)62.61 (17.61)