Mean (S.E.M.) effect of selected doses of CP55940, URB597, and AM404 alone and in combination with 3.0 mg/kg SR141716A
SR141716A significantly attenuated the effects of each drug in each assay (determined by unpaired by t tests with an α level of significance of 0.05).
| Drug Alone | + 3.0 mg/kg SR141716A | |
|---|---|---|
| Hotplate, %MPE | ||
| 1.0 mg/kg CP55940 | 100 (0.00) | 33.39 (8.30) |
| Acetic acid-elicited writhing, % inhibition | ||
| 0.32 mg/kg CP55940 | 99.98 (0.02) | 4.76 (15.57) |
| 10.0 mg/kg URB597 | 90.00 (4.19) | 13.02 (19.06) |
| 10.0 mg/kg AM404 | 37.78 (14.74) | 3.50 (3.06) |
| Acetic acid-suppressed feeding, % control | ||
| 10.0 mg/kg URB597 | 72.48 (11.90) | 5.58 (1.09) |
| Acetic acid-suppressed running, % control | ||
| 10.0 mg/kg URB597 | 54.08 (12.73) | 9.94 (5.82) |
| 10.0 mg/kg AM404 | 31.18 (9.87) | 5.09 (2.73) |
| Schedule-controlled behavior, % control | ||
| 0.1 mg/kg CP55940 | 1.06 (0.66) | 62.61 (17.61) |