TABLE 1

Characteristics of GABAergic PSCs recorded from CA1 pyramidal neurons in hippocampal slices in the continuous presence of 10 nM MLA

Recordings were obtained either during 15-min superfusion of the slices with 10 nM MLA or during superfusion that followed 2- to 5-h incubation with MLA. Data are presented as mean ± S.E.M. of results obtained from 10 neurons from five rats in ACSF, eight neurons from five rats in the MLA incubation, and six neurons from six rats in the MLA bath application.

TreatmentAmplitudeRise Time 10 to 90%τd
pAms
ACSF25.2 ± 0.732.34 ± 0.1936.1 ± 1.72
10 nM MLA bath exposure20.4 ± 0.441.67 ± 0.1942.1 ± 3.51
10 nM MLA incubation19.9 ± 0.921.78 ± 0.1840.7 ± 2.63