TABLE 3

Characteristics of GABAergic PSCs recorded from CA1 pyramidal neurons in hippocampal slices incubated with kynurenine (200 μM) alone or together with 10 nM MLA

Data are presented as mean ± S.E.M. of results obtained from eight neurons from eight rats in ACSF, six neurons from four rats in 200 μM l-kynurenine, and eight neurons from four rats in 200 μM l-kynurenine plus MLA.

TreatmentAmplitudeRise Time 10 to 90%τd
pAms
ACSF24.9 ± 0.832.25 ± 0.2139.3 ± 2.14
200 μM Kynurenine19.9 ± 0.962.07 ± 0.1243.5 ± 2.25
200 μM Kynurenine plus 10 nM MLA15.3 ± 0.44*1.73 ± 0.1852.4 ± 2.98
200 μM KYNA20.2 ± 0.892.02 ± 0.2440.8 ± 2.61
  • * P < 0.05 compared with control according to one-way ANOVA followed by Dunnett post hoc test.