TABLE 1

Effects of Inh-1 on the pharmacokinetic parameters of diclofenac

Male C57BL/6 mice were pretreated with Inh-1 (10 μg p.o., per mouse) or vehicle (0.5% methyl cellulose) b.i.d. for 2 consecutive days. Diclofenac (60 mg/kg i.p.) was administered 1 h after the last dose of Inh-1. Blood was drawn after 0.16, 0.5, 1, 2, 4, 8, and 24 h after diclofenac, and plasma drug concentrations were determined by LC-MS/MS. The data are mean ± S.D. (n = 3 mice for each time point; maximally three serial sampling times per mouse).