TABLE 5

Cutoff values for P450 mRNA levels relative to GADPH mRNA in liver tissues and leukocytes distinguishing poor (PM), intermediate (IM), and extensive (EM) metabolizers

Cutoff Values
PM-IMIM-EM
CYP1A2
    Liver4.5 × 10−21.5 × 10−1
    Leukocytes10−42 × 10−3
CYP2B6
    Liver3.5 × 10−21.5 × 10−1
    Leukocytes
CYP2C9
    Liver1.5 × 10−17 × 10−1
    Leukocytes5 × 10−62.5 × 10−5
CYP2C19
    Liver8 × 10−23.5 × 10−1
    Leukocytes10−610−5
CYP2D6
    Liver1.5 × 10−15 × 10−1
    Leukocytes
CYP3A4
    Liver2.5 × 10−11.5
    Leukocytes10−610−4