TABLE 4

Relationship between P450 enzyme activities and mRNA levels in liver and leukocytes

Spearman's correlation coefficients (rS), 95% confidence intervals (95% CI), and probability values (P) were calculated.

P450 ActivityP450 mRNA
LiverLeukocytes
CYP1A2
    Phenacetin O-dealkylationrs0.87800.8896
95% CI0.8058–0.92450.7868–0.9443
P<0.0001<0.0001
CYP2B6
    Mephenytoin N-demethylationrs0.8900−0.1824
95% CI0.8342–0.9278−04178–0.07595
P<0.00010.1525
CYP2C9
    Tolbutamide 4-hydroxylationrs0.92550.9179
95% CI0.8858–0.95180.8703–0.9485
P<0.0001<0.0001
CYP2C19
    Mephenytoin 4′-hydroxylationrs0.88080.8018
95% CI0.8160–0.92370.6792–0.8679
P<0.0001<0.0001
CYP2D6
    Dextromethorphan O-demethylationrs0.91300.07087
95% CI0.8532–0.9491−0.1939–0.3260
P<0.00010.5905
CYP3A
    Nifedipine oxidationrs0.89840.9475
95% CI0.8436–0.93460.9145–0.9680
P<0.0001<0.0001
    Midazolam 1′-hydroxylationrs0.81120.7718
95% CI0.7165–0.87650.6484–0.8557
P<0.0001<0.0001
    Midazolam 4-hydroxylationrs0.80010.8078
95% CI0.7005–0.87830.7005–0.8794
P<0.0001<0.0001