TABLE 3

Pharmacokinetic parameters for TEA, metformin, and cephalexin in control and cimetidine-treated mice

Each value was determined from the data shown in Fig. 8. The equations to determine the kinetic parameters are described under Materials and Methods. Each value represents the mean ± S.E. (n = 6).

ParameterTEAMetforminCephalexin
Control+CimetidineControl+CimetidineControl+Cimetidine
Cp,ss, μM1.87 ± 0.112.75 ± 0.30*1.73 ± 0.041.68 ± 0.05777 ± 24930 ± 44*
Ckidney, nmol/g kidney21.8 ± 5.5174 ± 19**8.91 ± 0.5920.8 ± 2.6**2.28 ± 0.109.02 ± 0.41**
Cliver, nmol/g liver44.7 ± 2.855.6 ± 7.44.1 ± 0.69.4 ± 0.51.05 ± 0.081.23 ± 0.14
Vurine, nmol/min/kg86 ± 454 ± 7**92 ± 294 ± 18.1 ± 0.25.9 ± 0.5**
Furine, %67 ± 342 ± 5**92 ± 294 ± 181 ± 259 ± 5**
CLtot, ml/min/kg74 ± 453 ± 7*58 ± 160 ± 213 ± 012 ± 0**
CLR, ml/min/kg49 ± 423 ± 5**54 ± 156 ± 110 ± 06.6 ± 0.3**
Kp, kidney, ml/g kidney11 ± 261 ± 5**5.0 ± 0.312 ± 1**2.9 ± 0.29.8 ± 0.5**
Kp, liver, ml/g liver24 ± 320 ± 32.3 ± 0.25.5 ± 0.3**1.3 ± 0.11.3 ± 0.3
  • Cp, ss, steady-state concentration; Ckidney, drug concentration in the kidney at 90 min (for TEA) or 120 min (for metformin and cephalexin); Cliver, drug concentration in the liver at 90 min (for TEA) or 120 min (for metformin and cephalexin); Vurine, urinary excretion rate; Furine, fractional urinary excretion ratio; CLtot, total body clearance; CLR, renal clearance with regard to the plasma concentration; Kp, kidney, kidney-to-plasma concentration ratio; Kp, liver, liver-to-plasma concentration ratio.

  • * P < 0.05;

  • ** P < 0.01.