TABLE 1

Pharmacokinetic drug-drug interactions caused by cimetidine in the tubular secretion

All of the renal clearance was significantly decreased by coadministration of cimetidine. Each value represents the mean ± S.D. (mean ± S.E.a).

DrugCimetidine DoseCLR, ControlCLR, +CimetidineImaxReference
μM
Amiloride400 mg b.i.d. for 12 days358 ± 134 ml/min299 ± 1187.57 ± 1.59Somogyi et al., 1989
Bisoprolol400 mg t.i.d. for 7 days8.3 ± 2.1 l/h4.6 ± 1.4N.D.Kirch et al., 1986
Cephalexin400 mg b.i.d. for 2 days263 ± 39 ml/min208 ± 217.57 ± 1.66van Crugten et al., 1986
Dofetilide100 mg b.i.d. for 2 days273.7 ± 38.7 ml/min237.5 ± 35.0N.D.Abel et al., 2000
Dofetilide400 mg b.i.d. for 2 days273.7 ± 38.7 ml/min184.3 ± 34.5N.D.Abel et al., 2000
Fexofenadine400 mg b.i.d. for 6 days230 ± 78 ml/min152 ± 70N.D.Yasui-Furukori et al., 2005
Levofloxacin400 mg b.i.d. for 4 days7.14 l/h5.46N.D.Fish and Chow, 1997
Metformin400 mg b.i.d. for 5 days527 ± 165 ml/min378 ± 1229.55 ± 2.42Somogyi et al., 1987
Metformin400 mg b.i.d. for 7 days10.4 ± 1.67 ml/min/kg5.76 ± 1.304.91 ± 2.69Wang et al., 2008
Nicotine600 mg b.i.d. for 2 days1.49 ± 0.30 ml/min/kg0.79 ± 0.30N.D.Bendayan et al., 1990
Pilsicainide400 mg 2 h before and simultaneously196.8 ± 53.9 ml/min141.8 ± 25.9N.D.Shiga et al., 2000
R-(+)-pindolol400 mg b.i.d. for 2 days170 ± 55 ml/min104 ± 18N.D.Somogyi et al., 1992
S-(−)-pindolol400 mg b.i.d. for 2 days222 ± 66 ml/min155 ± 38N.D.Somogyi et al., 1992
Procainamide400 and 200 mg every 4 h up to 12 h346.7 ± 46.2 ml/min196.4 ± 10.8N.D.Somogyi et al., 1983
Procainamidea300 mg q.i.d. for 4 days2.89 ± 0.24 ml/min/kg1.85 ± 0.12N.D.Christian et al., 1984
Procainamide300 mg q.i.d. for 4 days465.9 ± 78.3 ml/min297.4 ± 115.2N.D.Rodvold et al., 1987
Procainamidea200 mg415.8 ± 43.7 ml/min287.6 ± 18.6N.D.Lai et al., 1988
Procainamidea400 mg374.5 ± 42.0 ml/min225.2 ± 23.5N.D.Lai et al., 1988
Ranitidine400 mg b.i.d. for 2 days326 ± 67 ml/min244 ± 578.28 ± 1.86van Crugten et al., 1986
Temafloxacin400 mg t.i.d. for 5 days147.0 ± 27.4 ml/min120.0 ± 23.9N.D.Sorgel et al., 1992
Triamterene400 mg b.i.d. for 4 days71 ± 46 ml/min27 ± 147.17 ± 1.94Muirhead et al., 1986
Varenicline300 mg q.i.d. for 2 days133 ± 36 ml/min100 ± 28N.D.Feng et al., 2008
Zidovudine300 mg q.i.d. for 7 days0.41 ± 0.09 l/h/kg0.18 ± 0.04N.D.Fletcher et al., 1995
  • CLR (control) and CLR (+cimetidine), renal clearance with regard to the plasma concentration in control and cimetidine-treated conditions, respectively; Imax maximum plasma concentration of cimetidine; N.D., not determined.