Pharmacokinetic parameters of MDMA and MDA
Values are expressed as mean ± S.E.M. of 16 healthy subjects.
| Cmax | tmax | t1/2 | AUC0–6 | |
|---|---|---|---|---|
| ng/ml | h | ng/ml · h | ||
| MDMA | ||||
| Placebo-MDMA | 238 ± 10 | 2.5 ± 0.2 | 7.7 ± 0.7 | 1021 ± 35 |
| Clonidine-MDMA | 231 ± 11 | 2.5 ± 0.1 | 9.4 ± 0.9 | 1032 ± 51 |
| MDA | ||||
| Placebo-MDMA | 10.9 ± 0.7 | 5.2 ± 0.3 | N.A. | 42.3 ± 3.1 |
| Clonidine-MDMA | 11.2 ± 0.8 | 5.1 ± 0.4 | N.A. | 44.3 ± 3.4 |
tmax, time to maximum plasma concentration; t1/2, terminal elimination half-life; AUC, area under the plasma concentration-time curve; N.A., not assessed.