Li81 mAb, Fab2, Fab, and PEG-Fab levels in serum, brain, CSF, and spinal cord after systemic administration in Brown Norway rats
Each value is the mean of data from three rats. S.D. are given in parentheses.
| Test Article | Time | Serum | Brain | CSF | Spinal Cord |
|---|---|---|---|---|---|
| h | μg/ml | ng/ml | ng/ml | ng/ml | |
| Li 81 mAb, 30 mg/kg | 6 | 1000 (120) | 270 (64) | 28 (4) | 210 (50) |
| 24 | 430 (70) | 360 (140) | 340 (270) | 290 (49) | |
| 48 | 230 (65) | 290 (42) | 89 (16) | 440 (250) | |
| 96 | 216 (48) | 380 (150) | 38 (33) | 320 (160) | |
| 144 | 180 (52) | 380 (140) | 100 (70) | 400 (98) | |
| 192 | 160 (63) | 290 (110) | 34 (6) | 250 (65) | |
| 336 | 55 (28) | 130 (90) | 12 (10) | 160 (6) | |
| 720 | 7 (6) | 33 (30) | <5 | 48 (1) | |
| Li81 Fab2, 60 mg/kg | 6 | 630 (390) | 130 (71) | 700 (350) | 170 (150) |
| 24 | 250 (13) | 90 (6) | 640 (78) | 100 (85) | |
| 48 | 49 (6) | 47 (7) | 410 (170) | 54 (37) | |
| 96 | 3 (1) | 19 (6) | 48 (2) | 12 (7) | |
| 144 | 0.5 (0.1) | 12 (4) | 17 (21) | BLQ | |
| 192 | BLQ | BLQ | BLQ | BLQ | |
| Li81 Fab, 250 mg/kg | 6 | 510 (120) | 260 (120) | 230 (68) | 290 (160) |
| 24 | 31 (13) | 52 (19) | 35 (15) | 13 (11) | |
| 48 | 8 (4) | 44 (9) | BLQ | 1 (0.2) | |
| 96 | 0.7 (0.3) | BLQ | BLQ | BLQ | |
| 144 | BLQ | BLQ | BLQ | BLQ | |
| 192 | BLQ | BLQ | BLQ | BLQ | |
| Li81 PEG-Fab, 30 mg/kg | 6 | 310 (71) | 110 (40) | 310 (100) | 75 (49) |
| 24 | 230 (14) | 70 (8) | 610 (280) | 50 (6) | |
| 48 | 180 (35) | 100 (7) | 670 (47) | 120 (37) | |
| 96 | 45 (10) | 61 (31) | 550 (360) | 28 (28) | |
| 144 | 5 (0.2) | 23 (4) | 120 (59) | BLQ | |
| 192 | BLQ | BLQ | BLQ | BLQ |
BLQ, below limit of quantitation.