Strain & Tissue | Km | Vmax | Vmax/Km |
---|---|---|---|
μM | nmol · min−1 · mg protein−1 | ml · mg protein−1 · min−1 | |
WT | |||
Lung | 1.5 ± 0.2 | 0.5 ± 0.0 | 0.330 |
34.3 ± 2.2 | 1.0 ± 0.3 | 0.029 | |
Liver | 17.4 ± 1.4 | 1.2 ± 0.1 | 0.069 |
OM | 1.6 ± 0.3 | 0.5 ± 0.2 | 0.310 |
74.5 ± 22.6 | 0.9 ± 0.2 | 0.012 | |
Cyp2f2-null | |||
Lung | 100 ± 20a | 0.2 ± 0.0a | 0.002 |
Liver | 70.2 ± 12.4b | 1.2 ± 0.3 | 0.017 |
OM | 60.2 ± 11.0c | 1.1 ± 0.0d | 0.018 |
a P < 0.01 compared with either of the corresponding WT values.
b P < 0.01 compared with corresponding WT value.
c P < 0.01 compared with corresponding low-Km WT value.
d P < 0.01 compared with corresponding low-Km WT values.