TABLE 4

Lipopolysaccharaide-stimulated inflammatory mediator production from alveolar macrophages

Data are presented as mean (SD).

Levels of Baseline and LPS-Induced Cytokine
HNSSmokersCOPD
BaselineLPS InducedBaselineLPS InducedBaselineLPS Induced
pg/ml
IL-826,240 (30,430)299,500 (174,000)27,940 (49,500)324,300 (189,900)24,360 (41,760)190,000 (121,600)
IL-6419 (732)30,150 (9605)688 (1247)48,870 (23,420)311 (330)24,530 (1012)
TNF-α1086 (1768)26,020 (16,800)102 (45)23,400 (14,320)85 (52)14,130 (9587)
GM-CSF27 (38)721 (431)6 (1)442 (367)23 (38)302 (362)
IL-1 α220 (174)453 (147)18 (13)189 (195)154 (298)216 (382)
IL-1β20 (13)166 (185)49 (95)146 (104)42 (39)152 (169)
IL-1ra866 (960)4082 (2182)868 (506)5013 (2027)1479 (1855)5235 (3288)
IL-1042 (48)695 (468)7 (12)716 (302)56 (100)915 (492)
MCP-375 (88)308 (303)73 (47)1109 (645)256 (533)1576 (1243)
MDC2342 (2513)4596 (2902)1300 (701)3864 (1353)2168 (2358)3881 (2479)
RANTES102 (110)4228 (3910)36 (46)2413 (1125)1200 (2797)3354 (3637)