Summary of neuropathology results for the SOMAN and the SOMAN + LY293558 groups at 1 and 7 days after soman exposure
Shown is neuronal loss in the BLA and CA1 area for the total population of neurons and for the GABAergic neurons, expressed as percentage remaining compared with the controls. Also shown are neurodegeneration results (neuropathology scores from FJC stained-sections) in the amygdala (Amy), piriform cortex (Pir), entorhinal cortex (Ent), the CA1 and CA3 subfields of the hippocampus, hilus, and neocortex (Neo-Ctx). For neuropathology scores: R = range of scores; 0 = no FJC + cells; 1 = minimal damage (1–10%); 2 = mild damage (11–25%); 3 = moderate damage (26–45%); and 4 = severe damage (>45%).
| 1 day after soman | 7 days after soman | |||
|---|---|---|---|---|
| SOMAN n = 6 | SOMAN + LY293558 n = 5 | SOMAN n = 6 | SOMAN + LY293558 n = 6 | |
| Percentage remaining compared with control | ||||
| Total number of neurons | ||||
| BLA | 65** | 93 | 65*** | 88 |
| CA1 | 70** | 92 | 61** | 89 |
| GABAergic neurons | ||||
| BLA | 88 | 100 | 67* | 91 |
| CA1 | 88 | 96 | 89 | 94 |
| Irreversible neuronal degeneration | ||||
| Amy | Moderate (R = 3–4) | Mild† (R = 0–3) | Moderate (R = 2–4) | Minimal‡‡ (R = 0–2) |
| Pir | Moderate (R = 3–4) | Moderate (R = 0–4) | Moderate (R = 3–4) | Minimal (R = 0–4) |
| Neo-Ctx | Mild (R = 2–3) | Minimal† (R = 0–2) | Mild (R = 1–3) | Minimal† (R = 0–2) |
| CA1 | Severe (R = 3–4) | Minimal‡‡ (R = 0–3) | Severe (R = 3–4) | No FJC+‡‡ (R = 0–0) |
| CA3 | Severe (R = 3–4) | Minimal‡‡ (R = 0–3) | Moderate (R = 1–4) | No FJC+‡‡ (R = 0–0) |
| Hilus | Severe (R = 3–4) | Minimal† (R = 0–4) | Mild (R = 0–4) | No FJC+ (R = 0–0) |
| Ent | Moderate (R = 3–4) | Mild‡‡ (R = 0–2) | Moderate (R = 2–3) | Mild (R = 0–3) |