Permeability and transport of 2 μM PNU-288034 in Transwell monolayer efflux studies
Data are reported as the mean ± S.D., n = 3.
| Cell Line | Papp (A → B) | Papp (B → A) | B → A/A → B Efflux Ratio | Transporter/WT Ratio of Ratios |
|---|---|---|---|---|
| nm/s | ||||
| MDCK-WT | 12.4 ± 0.55 | 19.2 ± 0.28 | 1.55 ± 0.07 | — |
| MDCK-MDR1 | 13.8 ± 2.13 | 53.1 ± 1.70 | 3.86 ± 0.61 | 2.49 ± 0.41 |
| MDCK-BCRP | 9.87 ± 0.94 | 50.2 ± 2.77 | 3.33 ± 0.56 | 3.27 ± 0.39 |