TABLE 2

α7 binding density (fmol/mg protein) in rat hippocampus (HPC) and frontal cortex (FCX) after 1-week ABT-107 infusion (plasma Css = 0.2 ng/ml)

[3H]MLA[3H]A-585539
AverageS.E.M.AverageS.E.M.
HPC
    Control37.12.751.64
    ABT-10730.92.448.02.6
FCX
    Control24.51.325.21.5
    ABT-10723.61.423.21.1