TABLE 2

Summary of the potency of effects of nicotine in the locomotor activity and body temperature tests after acute administration in α5(+/+) and (−/+) mice

Potency is expressed as ED50 ± CL (milligrams per kilogram) for locomotor activity or ED ± CL (milligrams per kilogram) for body temperature. Each group contained 8 to 10 mice.

Testα5(+/+)α5(−/+)α5(−/−)
Locomotor activity0.44 (0.37–0.5)N.A.1.2 (1.1–1.4)*
Body temperature1.3 (1.1–1.6)1.8 (1.5–2.0)5.1 (4.3–5.7)*
  • N.A., not applicable.

  • * p < 0.05 denotes significance vs. α5(+/+) and α5(−/+) mice.