Summary of the potency of effects of nicotine in the locomotor activity and body temperature tests after acute administration in α5(+/+) and (−/+) mice
Potency is expressed as ED50 ± CL (milligrams per kilogram) for locomotor activity or ED6° ± CL (milligrams per kilogram) for body temperature. Each group contained 8 to 10 mice.
| Test | α5(+/+) | α5(−/+) | α5(−/−) |
|---|---|---|---|
| Locomotor activity | 0.44 (0.37–0.5) | N.A. | 1.2 (1.1–1.4)* |
| Body temperature | 1.3 (1.1–1.6) | 1.8 (1.5–2.0) | 5.1 (4.3–5.7)* |
N.A., not applicable.
↵* p < 0.05 denotes significance vs. α5(+/+) and α5(−/+) mice.