TABLE 1

Summary of the potency of the effects of nicotine in the tail-flick and hot-plate tests after acute administration in α5(+/+) and (−/+) mice

Potency is expressed as ED50 ± CL (milligrams per kilogram). Each group contained 8 to 10 mice.

Testα5(+/+)α5(−/+)
Tail-flick1.5 (1.2–1.7)2.3 (2.1–2.5)*
Hot-plate1.1 (0.9–1.5)3.1 (2.6–3.3)*

  • ↵* p < 0.05 denotes significance vs. α5 (+/+) mice.