Pharmacological parameters for 5-HT receptor agonist-induced contraction in endothelium-intact rat jugular vein
| Agonist | pD2= −log EC50 | Maximal Effect | na |
|---|---|---|---|
| mg | |||
| 5-HT | 6.65 ± 0.17 | 729 ± 83.4 | 13 |
| α-Methyl-5-HT | 7.23 ± 0.05 | 777 ± 108.5 | 5 |
| DOI | 7.76 ± 0.12 | 631 ± 59.1 | 8 |
| 5-Methoxytryptamine | 7.19 ± 0.04 | 627 ± 35.8 | 6 |
| 5-CT | 6.52 ± 0.40 | 502 ± 30.53 | 5 |
| BRL5443 | 7.32 ± 0.03 | 482 ± 12.4 | 4 |
| 8-OH-DPAT | 5.58 ± 0.06 | 329 ± 23.4 | 5 |
| BW723C86 | 6.17 ± 0.10 | 310 ± 47.8 | 8 |
| RU24969 | 6.38 ± 0.10 | 229 ± 23.7 | 6 |
| LP44 | N/A | 155 ± 31.8 | 8 |
| Sumatriptan | N/A | 10 ± 3.41 | 5 |
| Zacopride | N/A | N/A | 4 |
| EMD386088 | N/A | N/A | 6 |
N/A, could not be obtained.
↵a Number of experiments.