TABLE 5

Displacement of dopamine D2 antagonist radioligands in human striatum after oral amphetamine (∼0.5 mg · kg−1)

Healthy ControlRadioligandRegion of Interest
Ventral StriatumCaudatePutamenStriatum
This study[11C]Raclopride9.7 ± 4.48.4 ± 4.214.7 ± 4.812.3 ± 4.4
Ziolko et al. (2007)[11C]Raclopride11.3 ± 4.96.5 ± 5.014.0 ± 5.011.3 ± 4.9
Cárdenas et al. (2004)[11C]Raclopride13.3 ± 5.0
Busto et al. (2009)a[11C]Raclopride11.1 ± 3.6
Busto et al. (2009)b[11C]Raclopride14.2 ± 3.9
Riccardi et al. (2005)[18F]Fallypride7.2 ± 5.35.6 ± 4.611.2 ± 4.3
Cropley et al. (2008)[18F]Fallypride8.5 ± 2.87.6 ± 2.712.3 ± 2.8
  • a Healthy control smokers.

  • b Healthy control nonsmokers.