TABLE 4

Stimulant-induced decrease in [11C]raclopride VND in healthy controls

ReferencenStimulant ChallengeBaseline VNDPostchallenge VNDMean Difference
ml · cm3%
This study10Amphetamine, 0.5 mg/kg p.o.0.41 ± 0.070.38 ± 0.08*−7
Volkow et al. (1997)23Methylphenidate, 0.5 mg/kg i.v.0.42 ± 0.060.38 ± 0.08*−10
Wang et al. (1999)14Methylphenidate, 0.5 mg/kg i.v.−13
Volkow et al. (2001)11Methylphenidate, 0.8 mg/kg p.o.0.38 ± 0.050.36 ± 0.05−5
Drevets et al. (2001)6Amphetamine, 0.3 mg/kg i.v.0.38 ± 0.030.35 ± 0.03−6
Martinez et al. (2003)14Amphetamine, 0.3 mg/kg i.v.0.34 ± 0.080.34 ± 0.080
Martinez et al. (2005)15Amphetamine, 0.3 mg/kg i.v.0.40 ± 0.080.36 ± 0.08*−10
Martinez et al. (2007)24Amphetamine, 0.3 mg/kg i.v.0.39 ± 0.070.36 ± 0.07*−8
  • * Reported as statistically significant.