TABLE 2

Effect of amphetamine on [11C]raclopride and [11C]NPA BPND

Values are mean ± S.D.; n = 10 subjects.

Region[11C]Raclopride BPNDDifference[11C]NPA BPNDDifferenceΔ Ratio, NPA/Raclopride
BaselineAfter AmphetamineBaselineAfter Amphetamine
%
Ventral striatum2.43 ± 0.252.19 ± 0.25−9.7 ± 4.4*1.04 ± 0.100.88 ± 0.12−16.0 ± 7.0*1.64
Caudate2.49 ± 0.232.28 ± 0.20−8.4 ± 4.2*0.87 ± 0.100.73 ± 0.11−16.1 ± 6.1*1.90
Putamen3.29 ± 0.282.80 ± 0.21−14.7 ± 4.8*1.25 ± 0.100.97 ± 0.10−21.9 ± 4.9*1.49
Striatum2.91 ± 0.242.54 ± 0.19−12.3 ± 4.4*1.09 ± 0.090.88 ± 0.09−19.6 ± 4.3*1.59
  • * P < 0.001, paired t test.