Pharmacokinetic parameters of TEA in control and PYR-treated mice
Each value was determined from the data shown in Fig. 4 and the equations described under Materials and Methods. Each value represents the mean ± S.E. (n = 4–5).
| Parameter | PYR Dose | |||
|---|---|---|---|---|
| 0 | 0.2 | 0.5 | 2 | |
| μmol/kg | ||||
| Cp,ss (μM) | 1.73 ± 0.07 | 1.72 ± 0.09 | 1.92 ± 0.09 | 1.64 ± 0.12 |
| Ckidney (nmol/g kidney) | 10.6 ± 0.8 | 15.4 ± 2.5 | 20.8 ± 1.7* | 27.8 ± 3.5** |
| Cliver (nmol/g liver) | 20.9 ± 2.1 | 25.3 ± 2.3 | 35.1 ± 4.5* | 22.1 ± 2.8 |
| Vurine (nmol/min/kg) | 109 ± 7 | 96 ± 5 | 89 ± 6 | 106 ± 11 |
| Furine (%) | 85 ± 3 | 75 ± 5 | 69 ± 4 | 83 ± 2 |
| CLtot,plasma (ml/min/kg) | 76 ± 7 | 76 ± 7 | 68 ± 5 | 79 ± 5 |
| CLrenal, plasma (ml/min/kg) | 65 ± 8 | 57 ± 7 | 47 ± 6 | 66 ± 5 |
| CLrenal, kidney (ml/min/kg) | 7.8 ± 1.1 | 5.1 ± 0.9 | 3.1 ± 0.3** | 3.0 ± 0.4** |
| GFR (ml/min/kg) | 17 ± 1 | 14 ± 2 | 14 ± 1 | 17 ± 1 |
| Kp,kidney (ml/g kidney) | 6.2 ± 0.3 | 9.0 ± 1.3 | 11 ± 1* | 17 ± 1** |
| Kp,liver (ml/g liver) | 12 ± 1 | 15 ± 1 | 18 ± 1 | 14 ± 2 |
Cp, ss, steady-state concentration; Ckidney, drug concentration in the kidney at 90 min; Cliver, drug concentration in the liver at 90 min; Vurine, urinary excretion rate; Furine, fractional urinary excretion ratio; CLtot,plasma, total body clearance; CLrenal, plasma, renal clearance with respect to the concentration in circulating plasma; CLrenal, kidney, renal clearance with respect to the kidney concentration; Kp,kidney, kidney-to-plasma concentration ratio; Kp,liver, liver-to-plasma concentration ratio.
↵* p < 0.05.
↵** p < 0.01.