TABLE 1

Summary of STZ-induced mRNA changes in wild-type and Nrf2-null mice

Wild TypeNrf2-Null
Glucose uptake/synthesis
    Glut2 transporter
    Glucose-6-phosphatase
    PEPCK?
Glycolytic enzymes
    Glucokinase
    Pyruvate kinase liver-type↔ (↓)*
    6-Phosphofructo-2-kinase
Glycogen synthesis/metabolism
    Glycogen synthase 2
    Glycogen phosphorylase
Fatty acid uptake/synthesis
    Steroyl-CoA desaturase 1
    Fatty acid synthase
    Fatty acid translocase (CD36)
    Malic enzyme↔ (↓)*
    Acetyl-coenzyme A carboxylase
    Fatty acid elongase
Fatty acid metabolism/export
    Carnitine palmitoyltransferase 1
    Malonyl-CoA decarboxylase
    Acyl-coenzyme A oxidase 1
Cholesterol and lipoprotein-related metabolism/transport
    Scavenger receptor B1
    Lecithin-cholesterol acyltransferase
    Low-density lipoprotein receptor-related protein 1
    3-Hydroxy-3-methylglutaryl-CoA reductase
    3-Hydroxy-3-methylglutaryl-CoA synthase
    ATP-binding cassette transporter A1
    Microsomal triglyceride transfer protein
    Apolipoprotein A1
    Apolipoprotein B1
    Apolipoprotein E
    Low-density lipoprotein receptor
  • (↓)* designates genes that are basally lower in Nrf2-null mice.