Comparison of IC50 values of naringin for OATP/Oatp and MDR1/Mdr1-mediated talinolol transport between humans and rats
| Species | Transporter | Naringin IC50a |
|---|---|---|
| μM | ||
| Human | MDR1 | >2000 (or not inhibited) |
| OATP1A2 | 343 ± 119 | |
| OATP2B1 | >2000 (or not inhibited) | |
| Rat | Mdr1a | 604 ± 169 |
| Oatp1a5 | 12.7 ± 3.1 |
↵a IC50 values were obtained from Figs. 2 and 6.