Maximal brain concentration (Cmax) of drugs and metabolites after injection (subcutaneous) of 5 and 15 μmol/kg heroin, 6MAM, and morphine Values are mean ± S.E.M., n = 4 to 8 mice.
| Injected Drug | Cmax | |||
|---|---|---|---|---|
| Heroin | 6MAM | Morphine | M3G | |
| nmol/g | ||||
| Heroin, 5 μmol/kg | 0.03 ± 0.019 | 0.83 ± 0.038* | 0.20 ± 0.025‡ | N.D. |
| Heroin, 15 μmol/kg | 0.21 ± 0.051 | 4.70 ± 0.706† | 0.73 ± 0.028§ | 0.02 ± 0.011 |
| 6MAM, 5 μmol/kg | 0.61 ± 0.049 | 0.20 ± 0.013‡ | N.D. | |
| 6MAM, 15 μmol/kg | 2.26 ± 0.203 | 0.46 ± 0.056 | 0.07 ± 0.052 | |
| Morphine, 5 μmol/kg | 0.11 ± 0.005 | N.D. | ||
| Morphine, 15 μmol/kg | 0.45 ± 0.021 | 0.07 ± 0.018 | ||
N.D., not determined.
↵* Significant difference compared with 6MAM injected, F(1,6) = 12.072; p < 0.05.
↵† Significant difference compared with 6MAM injected, F(1,10) = 10.994; p < 0.01.
↵‡ Significant difference compared with morphine injected, F(2,10) = 9.147; p < 0.05.
↵§ Significant difference compared with morphine injected, F(2,12) = 17.577; p < 0.001.