Peff and ER values of [14C]dasatinib across wild-type and Bcrp1-transfected MDCKII cell monolayers in the presence and absence of BCRP inhibitor Ko143
MDCK Wild Type (Control) | MDCK Bcrp1-Transfected | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| A-to-B Peff | B-to-A Peff | ER | A-to-B Peff | B-to-A Peff | ER | |||||
| mean ± S.D. × 10–6 cm/s | ||||||||||
| Treatment control | 3.09 ± 0.61 | 12.73 ± 0.60* | 4.1 | 0.31 ± 0.25 | 16.20 ± 0.66* | 51.6 | ||||
| 200 nM Ko143 | 2.60 ± 0.10 | 10.68 ± 0.63* | 4.1 | 1.66 ± 0.10† | 15.19 ± 0.56* | 9.2 | ||||