Peff and ER values of [14C]dasatinib across wild-type and MDR1-transfected MDCKII cell monolayers, in the presence and absence of P-gp inhibitor LY335979
MDCK Wild Type (Control) | MDCK MDR1-Transfected | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
A-to-B Peff | B-to-A Peff | ER | A-to-B Peff | B-to-A Peff | ER | |||||
mean ± S.D. × 10–6 cm/s | ||||||||||
Treatment control | 2.02 ± 0.33 | 9.64 ± 0.98* | 4.8 | 0.45 ± 0.05 | 11.58 ± 0.65* | 25.6 | ||||
1 μM LY335979 | 5.16 ± 0.15† | 4.83 ± 0.19† | 0.9 | 3.79 ± 0.37† | 4.53 ± 0.10† | 1.2 |