TABLE 1

P_eff and ER values of [¹⁴C]dasatinib across wild-type and MDR1-transfected MDCKII cell monolayers, in the presence and absence of P-gp inhibitor LY335979

	MDCK Wild Type (Control)					MDCK MDR1-Transfected
	A-to-B P_eff	B-to-A P_eff	ER	A-to-B P_eff	B-to-A P_eff	ER
					mean ± S.D. × 10^–6 cm/s
Treatment control	2.02 ± 0.33	9.64 ± 0.98^*	4.8	0.45 ± 0.05	11.58 ± 0.65^*	25.6
1 μM LY335979	5.16 ± 0.15^†	4.83 ± 0.19^†	0.9	3.79 ± 0.37^†	4.53 ± 0.10^†	1.2

↵* p < 0.001 compared with A-to-B transport
↵† p < 0.001 compared with treatment control