TABLE 1

Pharmacokinetic parameters derived from serum concentrations Average of three animals per time point ± S.D.

Component
Dosea
t1/2 β
AUC 0–10 Days
Cl
Vd ss
nmol/kg days nM * day l/kg/day l/kg
14C (mcMMAF) 23 2.27 ± 0.27 318.9 ± 27.5 0.072 ± 0.006 0.21 ± 0.01
3H (mAb)
10
2.54 ± 0.44
199.6 ± 19.7
0.051 ± 0.008
0.17 ± 0.01

  • t1/2 β, terminal half-life; AUC, area under the curve; Cl, clearance; Vd ss, volume of distribution at steady state

  • ↵ a Mole equivalents in the 1.5 mg/kg dose of ADC