Effect of 10 μM A-867744 on the choline-evoked α7 current parameters in hippocampus CA1 stratum radiatum interneurons Cell capacitance was 29.7 ± 3.5 (n = 4).
| Parameter | Control (n = 4) | A-867744 (n = 4) |
|---|---|---|
| Peak current amplitude (pA) | –861.0 ± 249.1 | –1665.5 ± 304.8 (p < 0.02) |
| Peak current density (pA/pF) | –28.3 ± 5.6 | –55.1 ± 4.2 (p < 0.02) |
| Total charge (pA · ms) | –133,433 ± 70,565 | –454,440 ± 127,110 (p < 0.02) |
| Half-width (ms) | 65.8 ± 28.7 | 219.1 ± 23.2 (p < 0.002) |
| 10 to 90% rise slope (pA/ms) | –117.5 ± 36.8 | –58.0 ± 15.0 (p = 0.08) |
| Tau current decay (ms) | 79.4 ± 31.9 | 201.7 ± 28.2 (p < 0.02) |