TABLE 1

Effect of intrarenal infusion of NaHS on renal hemodynamics and urinary excretory functions


NaHS (nmol/min/kg)

C

C

5

10

20

40

80
MAP (mm Hg) 107.8 ± 1.74 107.7 ± 1.72 107.5 ± 1.80 107.8 ± 1.79 107.2 ± 1.89 105.5 ± 1.58 106.1 ± 1.63
RBF (ml/min/g kwt) 8.99 ± 0.91 9.12 ± 0.94 9.12 ± 0.93 9.25 ± 0.93 9.73 ± 0.90* 10.59 ± 1.03* 10.55 ± 1.03*
GFR (ml/min/g kwt) 1.02 ± 0.10 1.04 ± 0.07 1.09 ± 0.08 1.26 ± 0.02* 1.32 ± 0.04* 1.57 ± 0.06* 1.79 ± 0.04*
U·V (μl/min/g kwt) 17.7 ± 1.70 17.2 ± 0.89 19.8 ± 2.07 26.0 ± 1.31* 39.1 ± 4.94* 53.7 ± 5.87* 81.3 ± 3.57*
UNa·V (μmol/min/g kwt) 2.72 ± 0.35 2.71 ± 0.53 2.96 ± 0.22 3.69 ± 0.21* 5.27 ± 0.70* 12.28 ± 1.31* 19.53 ± 1.40*
UK·V (μmol/min/g kwt) 1.69 ± 0.16 1.73 ± 0.26 1.82 ± 0.22 2.14 ± 0.26* 2.37 ± 0.19* 4.46 ± 0.33* 6.36 ± 0.59*
FF (%) 20.39 ± 1.47 20.65 ± 1.36 21.51 ± 1.31 24.71 ± 1.06* 25.77 ± 1.28* 26.95 ± 1.29* 30.86 ± 1.55*
FENa (%) 1.83 ± 0.25 1.84 ± 0.21 2.04 ± 0.18 2.26 ± 0.08* 3.02 ± 0.11* 5.39 ± 0.15* 7.52 ± 0.24*
FEK (%)
33.53 ± 7.39
33.65 ± 3.30
34.37 ± 5.19
37.13 ± 2.14*
45.88 ± 4.33*
57.77 ± 6.04*
71.03 ± 7.86*
  • * P < 0.05 vs. control (C) by repeated measures ANOVA