Effects of presession treatments with citalopram or nisoxetine on cocaine self-administration
Treatment | Response Rate Maintained at 0.32 mg/kg/Injection of Cocaine | Total Cocaine Intake within the Session |
|---|---|---|
| responses/s | mg/kg | |
| Vehicle | 0.40 (±0.19) | 9.3 (±1.2) |
| Citalopram (3.2 mg/kg) | 0.23 (±0.06) | 6.9 (±1.5) |
| Citalopram (10.0 mg/kg) | 0.29 (±0.09) | 9.1 (±1.4) |
| Citalopram (32.0 mg/kg) | 0.21 (±0.04) | 8.5 (±0.8) |
| Citalopram (100.0 mg/kg) | 0.12 (±0.03) | 5.9 (±1.0) |
| Nisoxetine (3.2 mg/kg) | 0.25 (±0.08) | 8.6 (±1.2) |
| Nisoxetine (10.0 mg/kg) | 0.45 (±0.24) | 9.8 (±1.6) |
| Nisoxetine (32.0 mg/kg) | 0.27 (±0.13) | 8.4 (±1.3) |
| Nisoxetine (100.0 mg/kg) | 0.24 (±0.11) | 7.8 (±1.4) |