TABLE 1

Summary of pharmacodynamic parameters estimated from A375 and Colo205 xenograft studies

Parametera
A375 Melanoma Xenografts
Colo205 Colorectal Carcinoma Xenografts
kng (h–1) 0.0035 (1.1) 0.0039 (1.8)
Kmax (h–1) 0.030 (12.0) 0.028 (26.1)
KC50 (μM) 8.80 (16.0) 19.98 (38.9)
n 3.02 (29.1) 1.00 (fixed)
ED50 (mg/kg)b 28 32
Cstasis (μM)
4.48
3.27

  • ↵ a Fitted parameters are expressed as estimate followed by the coefficient of variation in parentheses

  • ↵ b ED50 doses were estimated by simulation as described under Materials and Methods