TABLE 5

Ki values of ABC and AZT inhibition of [3H]3TC uptake in CHO-hOCT1, -hOCT2, and -hOCT3 Data are shown as Ki values ± S.E.M. from at least three independent experiments, with each point performed in quadruplicate.


NRTIs

Ki
hOCT1
hOCT2
hOCT3
nM
ABC 0.330 ± 0.280 0.006 ± 0.004 0.070 ± 0.045
AZT
0.021 ± 0.016
0.205 ± 0.098
0.030 ± 0.021