IC50 values for high-affinity binding site and low-affinity binding site for inhibition of [3H]MPP+ uptake (0.0125, 0.125, or 5.0 μM) by 3TC in CHO-hOCT1 The statistical comparison between reference IC50 value ([MPP+] at 0.0125 μM) and the other two MPP+ concentrations was done (*, p < 0.05).
[MPP+] (μM) | CHO-hOCT1: IC50 Values of 3TC Two-Binding Sites | ||
|---|---|---|---|
| High-Affinity Binding Site | Low-Affinity Binding Site | ||
| pM | mM | ||
| 0.0125 | 12.3 ± 0.25 | 1.90 ± 0.14 | |
| 0.125 | 145.5 ± 2.15* | 1.12 ± 0.07 | |
| 5.0 | 2127.5 ± 38.5* | 1.42 ± 0.08 | |
↵* p < 0.05, IC50 different from the reference one (0.0125 μM MPP+)