IC50 values for inhibition of [3H]MPP+ uptake by NRTIs in CHO-hOCT1, -hOCT2, and -hOCT3 cell lines Data are shown as IC50 values ± S.E.M. from at least three independent experiments, with each point performed in quadruplicate.
NRTIs | IC50 | ||||
|---|---|---|---|---|---|
| hOCT1 | hOCT2 | hOCT3 | |||
| nM | |||||
| ABC | 0.072 ± 0.033 | 0.041 ± 0.020 | 0.050 ± 0.029 | ||
| AZT | 0.155 ± 0.111 | 0.270 ± 0.105 | 0.396 ± 0.270 | ||
| FTC | 0.020 ± 0.006 | 2.400 ± 1.162 | 0.530 ± 0.260 | ||
| TDF | 0.854 ± 0.012 | 0.566 ± 0.549 | 0.005 ± 0.003 | ||