TABLE 1

IC50 values for inhibition of [3H]MPP+ uptake by NRTIs in CHO-hOCT1, -hOCT2, and -hOCT3 cell lines Data are shown as IC50 values ± S.E.M. from at least three independent experiments, with each point performed in quadruplicate.


NRTIs

IC50
hOCT1
hOCT2
hOCT3
nM
ABC 0.072 ± 0.033 0.041 ± 0.020 0.050 ± 0.029
AZT 0.155 ± 0.111 0.270 ± 0.105 0.396 ± 0.270
FTC 0.020 ± 0.006 2.400 ± 1.162 0.530 ± 0.260
TDF
0.854 ± 0.012
0.566 ± 0.549
0.005 ± 0.003