TABLE 1

EC50 values for SB-206553 and PNU-120596 potentiation of α7 nAChR functional response in the presence of an EC20 concentration of nicotine using FLIPR and antagonist activities (percentage inhibition at 10 μM) for nAChR selectivity targets



Activation Effects: α7 nAChR EC50 (μM); Emax

Inhibition Effects

α1
α3
α4/β2
5-HT3
SB-206553 1.5; 82 15 24 0 23
PNU-120596
0.1; 203
6
0
8
24