In vitro activities of PF-03716556, revaprazan, and omeprazole Data are mean ± S.E.M.
pIC50 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ion-Leaky Assay | Ion-Tight Assay Porcine | Na+,K+-ATPase Canine Kidney | |||||||
| Porcine | Canine | Human Recombinant | |||||||
| PF-03716556 | 6.026 ± 0.112 | 6.038 ± 0.039 | 6.009 ± 0.209 | 7.095 ± 0.077 | <4 | ||||
| Revaprazan | 6.009 ± 0.209 | 6.323 ± 0.015 | <4 | ||||||
| Omeprazole | 6.038 ± 0.039 |
|
| 5.763 ± 0.196 | <4 | ||||