Rat | Scaling Factor | Human | |||
---|---|---|---|---|---|

In Vitro | In Vivo | In Vitro | In Vivo^{*} | ||

ml/min/g liver | ml/min/g liver | ||||

PS_{inf} | 2.47 (32.8)^{a,b} | 9.06^{g} | 3.7 | 0.448 | 1.66 |

PS_{dif} | 0.192^{a,b} | 0.192^{e} | 1^{e} | 0.0924 | 0.0924 |

PS_{bile} | |||||

ATP-dependent | 0.0433^{c} | 0.906^{d} (92.3) | 21 | 0.00737^{c} | 0.154 |

Nonsaturable | 0.234^{d} | 0.234^{f} | |||

CL_{met,int} | 0.793 | 1.33^{h} | 1.7 | 0 | 0 |

(0.846, 80.3) |

↵* Predicted by multiplying the in vitro parameter by the SF.

↵a Yamazaki et al. (1993).

↵b Ishigami et al. (1995).

↵c Calculated using eq. 3 (Niinuma et al. (1999)).

↵d Yamazaki et al. (1997).

↵e Assumed that the SF for PS

_{dif}is 1.↵f Assumed negligible interspecies difference between rat and human.

↵g Calculated using eq. 5.

↵h Calculated using eq. 4.