TABLE 5

Dexamethasone- and SB706504-responsive inflammatory mediator probe sets in COPD MDMs whereby LPS has no effect or suppresses expression


Name

Affymetrix Identification

Description

Fold Change
LPSa
Dexamethasoneb
SB706504b
Dexamethasone and SB706504b
IL1RN 216243_s_at Interleukin 1 receptor antagonist N.S. -5.95 -3.13 -8.07
TNFSF10 202687_s_at TNF (ligand) superfamily, member 10 N.S. -3.99 -2.62 -9.52
CXCL11 211122_s_at Chemokine (C-X-C motif) ligand 11 N.S. -3.76 N.S. -11.95
CSF1 211839_s_at Colony-stimulating factor 1 (macrophage) N.S. -4.22 N.S. -4.16
TNFSF7 206508_at TNF (ligand) superfamily, member 7 N.S. -2.04 N.S. -3.13
PBEF1 1555167_s_at Pre-B-cell colony-enhancing factor 1 N.S. N.S. -2.83 -3.71
PF4 206390_x_at Platelet factor 4 [chemokine (C-X-C motif) ligand 4] N.S. N.S. N.S. 2.08
LTB 207339_s_at Lymphotoxin β (TNF superfamily, member 3) N.S. N.S. N.S. -2.52
XCL2 214567_s_at Chemokine (C motif) ligand 2 N.S. N.S. N.S. -3.75
FASLG 210865_at Fas ligand (TNF superfamily, member 6) N.S. N.S. N.S. -2.93
TNFSF12 205611_at TNF (ligand) superfamily, member 12 -2.72 2.45 3.09 2.39
TNFSF14
207907_at
TNF (ligand) superfamily, member 14
-5.00
N.S.
2.65
N.S.
  • p < 0.01 unless fold change stated as N.S.

  • a Fold change is relative to unstimulated MDMs

  • b Fold change is LPS-stimulated MDMs plus drug relative to LPS only-stimulated MDMs